Sarcopenia corresponds to the degenerative loss of skeletal muscle mass, quality, and
strength associated with ageing and leads to a progressive impairment of mobility and …

The molecular mechanisms underlying skeletal muscle aging and associated sarcopenia
have been linked to an altered oxidative status of redox-sensitive proteins. Reactive oxygen …

Age-related loss of muscle mass and function is associated with increased frailty and loss of
independence. The mechanisms underlying the susceptibility of different muscle types to …

Skeletal muscle ageing is characterized by a progressive and dramatic loss of muscle mass
and strength leading to decreased muscular function resulting in muscle weakness which is …

Extended longevity is often accompanied by frailty and increased susceptibility to a variety of
crippling disorders. One of the most striking features of human aging is sarcopenia, which is …

Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

Oxidatively modified proteins build-up with age results, at least in part, from the increase of
reactive oxygen species and other toxic compounds originating from both cellular …

Skeletal muscle represents a physiologically relevant model for the application of redox
proteomic techniques to dissect its response to exercise and aging. Contracting skeletal …

Increased oxidative damage and disrupted redox signalling are consistently associated with
age-related loss of skeletal muscle mass and function. Redox signalling can directly …

According to the free-radical theory of aging, oxidative stress is a key contributor to the onset
of age-related conditions by inducing structural and functional alterations in several cellular …