BACKGROUND Hepsin is a cell surface protease that is over‐expressed in more than 90%
of human prostate cancer cases. The previously developed Probasin‐hepsin/Large …

Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP),
has been highlighted by several studies analyzing CaP-specific gene expression alterations …

The majority of cancer-related deaths are associated with metastasis; however, little is
known about the mechanisms of this process. Hepsin is a cell surface serine protease that is …

The hepsin gene encodes a type II transmembrane serine protease. Previous studies have
shown the overexpression of hepsin in prostate cancer, and the dysregulation of hepsin …

[Frontiers in Bioscience 12, 5052-5059, September 1, 2007] 5052 Hepsin and prostate cancer
Qingyu Wu1, Gordon Parry2 1Department Page 1 [Frontiers in Bioscience 12, 5052-5059 …

Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …

The transmembrane serine protease hepsin is one of the most highly upregulated genes in
prostate cancer. Here, we investigated its tumor-promoting activity by use of a mouse …

Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this
fact, many of the genetic changes that coincide with prostate cancer progression remain …

The serine-protease hepsin is one of the most prominently overexpressed genes in human
prostate carcinoma. Forced expression of the enzyme in mice prostates is associated with …

Objective Although many studies have documented the tumor-promoting role of hepsin in
several types of malignancies, little is known about its clinical and biological significance in …