Methotrexate (MTX) has been used as an anchor drug for the treatment of rheumatoid
arthritis (RA), while the patients with chronic MTX administration suffer from severe side …

Background Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA)
treatment, however, MTX does not accumulate well at inflamed sites, and long-term …

A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a
comprehensive system for treating osteoarthritis (OA), and the drug loading amount and …

After entering the human body, drugs for treating diseases are affected by various factors,
which are prone to delivery and release in an uncontrolled manner. Based on this, many …

Controlled structure, tunable porosity, and readily chemical functionalizability make metal-
organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been …

Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-
responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint …

Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are
polarized into the pro‐inflammatory M1 phenotype with significant oxidative stress and …

Abstract Metal-organic frameworks (MOFs), comprised of organic ligands and metal
ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their …

Oral drug administration is the preferred method for delivering medications due to its safety,
ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide …

Nanoparticle-based therapeutics have received increasing attention, as these systems can
alleviate many drawbacks of conventional therapy. Metal–organic frameworks (MOFs), a …