Multi-electrode array technologies for neuroscience and cardiology

ME Spira, A Hai - Nature nanotechnology, 2013 - nature.com
At present, the prime methodology for studying neuronal circuit-connectivity, physiology and
pathology under in vitro or in vivo conditions is by using substrate-integrated microelectrode …

Long-term, multisite, parallel, in-cell recording and stimulation by an array of extracellular microelectrodes

A Hai, J Shappir, ME Spira - Journal of neurophysiology, 2010 - journals.physiology.org
Here we report on the development of a novel neuroelectronic interface consisting of an
array of noninvasive gold-mushroom-shaped microelectrodes (gMμEs) that practically …

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices

U Frey, U Egert, F Heer, S Hafizovic… - Biosensors and …, 2009 - Elsevier
There is an enduring quest for technologies that provide–temporally and spatially–highly
resolved information on electric neuronal or cardiac activity in functional tissues or cell …

Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015 - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

Biological application of microelectrode arrays in drug discovery and basic research

A Stett, U Egert, E Guenther, F Hofmann… - Analytical and …, 2003 - Springer
Electrical activity of electrogenic cells in neuronal and cardiac tissue can be recorded by
means of microelectrode arrays (MEAs) that offer the unique possibility for non-invasive …

The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

IL Jones, P Livi, MK Lewandowska, M Fiscella… - Analytical and …, 2011 - Springer
Planar microelectrode arrays (MEAs) are devices that can be used in biomedical and basic
in vitro research to provide extracellular electrophysiological information about biological …

Growing cells atop microelectronic chips: interfacing electrogenic cells in vitro with CMOS-based microelectrode arrays

A Hierlemann, U Frey, S Hafizovic… - Proceedings of the …, 2010 - ieeexplore.ieee.org
Complementary semiconductor-metal-oxide (CMOS) technology is a very powerful
technology that can be more or less directly interfaced to electrogenic cells, like heart or …

Soft conductive micropillar electrode arrays for biologically relevant electrophysiological recording

Y Liu, AF McGuire, HY Lou, TL Li… - Proceedings of the …, 2018 - National Acad Sciences
Multielectrode arrays (MEAs) are essential tools in neural and cardiac research as they
provide a means for noninvasive, multiplexed recording of extracellular field potentials with …

Networks of neurons coupled to microelectrode arrays: a neuronal sensory system for pharmacological applications

M Chiappalone, A Vato, M Marcoli, F Davide… - Biosensors and …, 2003 - Elsevier
Two main features make microelectrode arrays (MEAs) a valuable tool for
electrophysiological measurements under the perspective of pharmacological applications …

Implantable microelectrode arrays for simultaneous electrophysiological and neurochemical recordings

MD Johnson, RK Franklin, MD Gibson… - Journal of Neuroscience …, 2008 - Elsevier
Implantable microfabricated microelectrode arrays represent a versatile and powerful tool to
record electrophysiological activity across multiple spatial locations in the brain. Spikes and …