Hepsin is a type II transmembrane serine protease overexpressed in the majority of human
prostate cancers. We recently demonstrated that hepsin promotes prostate cancer …

Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and
known to be involved in the progression of metastasis. Here we report a structure-guided …

The development of effective therapies inhibiting prostate cancer progression and
metastasis may substantially impact prostate cancer mortality and potentially reduce the …

Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …

Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP),
has been highlighted by several studies analyzing CaP-specific gene expression alterations …

The majority of cancer-related deaths are associated with metastasis; however, little is
known about the mechanisms of this process. Hepsin is a cell surface serine protease that is …

The hepsin gene encodes a type II transmembrane serine protease. Previous studies have
shown the overexpression of hepsin in prostate cancer, and the dysregulation of hepsin …

Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this
fact, many of the genetic changes that coincide with prostate cancer progression remain …

Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in
the human liver and tumours of the prostate and ovaries. To better understand the biological …

Hepsin is a membrane-anchored serine protease whose role in hepatocyte growth factor
(HGF) signaling and epithelial integrity makes it a target of therapeutic interest in …