Highlights•Several intranasal SARS-CoV-2 vaccines are now in use and induce mucosal
immunity.•Live-attenuated SARS-CoV-2 as nasal vaccines would induce hybrid …

The global rollout of COVID-19 vaccines has played a critical role in reducing pandemic
spread, disease severity, hospitalizations, and deaths. However, the first-generation …

Introduction As underlined by the late 2019 outbreak of severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), vaccination remains the cornerstone of global health-care …

The rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no
prophylactic vaccine is available. Here, we report the generation of a replication …

The worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the unprecedented pace of …

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has illustrated the critical
need for effective prophylactic vaccination to prevent the spread of severe acute respiratory …

Several effective SARS-CoV-2 vaccines are currently in use, but effective boosters are
needed to maintain or increase immunity due to waning responses and the emergence of …

The ongoing SARS-CoV-2 pandemic is controlled but not halted by public health measures
and mass vaccination strategies which have exclusively relied on intramuscular vaccines …

The development of more effective, accessible, and easy to administer COVID-19 vaccines
next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is …

The ongoing SARS-CoV-2 pandemic poses a severe global threat to public health, as do
influenza viruses and other coronaviruses. Here, we present chimpanzee adenovirus 68 …