Abstract The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent
need for effective preventive vaccination to reduce burden and spread of severe acute …

Viruses that replicate in the human respiratory mucosa without infecting systemically,
including influenza A, SARS-CoV-2, endemic coronaviruses, RSV, and many other" …

Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

The rapid development and deployment of vaccines following the emergence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to have saved …

Background Intranasal vaccination may induce protective local and systemic immune
responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine …

The efficacy of many coronavirus disease 2019 (COVID-19) vaccines has been shown to
decrease to varying extents against new severe acute respiratory syndrome coronavirus 2 …

Vaccination strategies that can induce a broad spectrum immune response are important to
enhance protection against SARS-CoV-2 variants. We conducted a randomized, double …

A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the …

Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for
which we typically have little or no prior immunity can result in epidemics with high morbidity …

The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a
global health priority. We evaluated the protective activity of a chimpanzee adenovirus …