COVID-19 vaccines for optimizing immunity in the upper respiratory tract

R Ramasamy - Viruses, 2023 - mdpi.com
Rapid development and deployment of vaccines greatly reduced mortality and morbidity
during the COVID-19 pandemic. The most widely used COVID-19 vaccines approved by …

A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice

E Kim, FJ Weisel, SC Balmert, MS Khan… - European journal of …, 2021 - Wiley Online Library
Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel
coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the …

The next set of COVID-19 vaccines: leveraging new development platforms to increase access for more people around the world

R Jhaveri - Clinical Therapeutics, 2021 - Elsevier
The approval of the coronavirus disease 2019 (COVID-19) mRNA vaccines brought much
optimism to efforts to end the pandemic. A recombinant adenovirus vaccine recently …

[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …

A bacterial extracellular vesicle‐based intranasal vaccine against SARS‐CoV‐2 protects against disease and elicits neutralizing antibodies to wild‐type and Delta …

L Jiang, TAP Driedonks, WSP Jong… - Journal of …, 2022 - Wiley Online Library
Several vaccines have been introduced to combat the coronavirus infectious disease‐2019
(COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …

Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination

J Tang, C Zeng, TM Cox, C Li, YM Son, IS Cheon… - Science …, 2022 - science.org
SARS-CoV-2 mRNA vaccination induces robust humoral and cellular immunity in the
circulation; however, it is currently unknown whether it elicits effective immune responses in …

A China-developed adenovirus vector-based COVID-19 vaccine: review of the development and application of Ad5-nCov

SY Wang, WQ Liu, YQ Li, JX Li… - Expert Review of Vaccines, 2023 - Taylor & Francis
Introduction The global spread of COVID-19 has prompted the development of vaccines. A
recombinant adenovirus type-5 vectored COVID-19 vaccine (Ad5-nCoV) developed by …

A comprehensive overview of vaccines developed for pandemic viral pathogens over the past two decades including those in clinical trials for the current novel SARS …

K Damodharan, GS Arumugam, S Ganesan, M Doble… - RSC …, 2021 - pubs.rsc.org
The unprecedented coronavirus disease 2019 (COVID-19) is triggered by a novel strain of
coronavirus namely, Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) …

Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2

H Cao, J Mai, Z Zhou, Z Li, R Duan, J Watt, Z Chen… - Cell & Bioscience, 2021 - Springer
Background The ongoing COVID-19 pandemic has resulted in 185 million recorded cases
and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for …

Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …