Localized and systemic immune responses against SARS-CoV-2 following mucosal immunization
The rapid transmission of SARS-CoV-2 in the USA and worldwide necessitates the
development of multiple vaccines to combat the COVID-19 global pandemic. Previously, we …
development of multiple vaccines to combat the COVID-19 global pandemic. Previously, we …
[HTML][HTML] Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have
focused on systemic immunization, here we compared the protective efficacy of 2 …
focused on systemic immunization, here we compared the protective efficacy of 2 …
Protection against SARS-CoV-2 transmission by a parenteral prime—Intranasal boost vaccine strategy
Background Licensed vaccines against SARS-CoV-2 effectively protect against severe
disease, but display incomplete protection against virus transmission. Mucosal vaccines …
disease, but display incomplete protection against virus transmission. Mucosal vaccines …
The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses
Emerging coronaviruses (CoV) are constant global public health threats to society. Multiple
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
ongoing clinical trials for vaccines and antivirals against CoVs showcase the availability of …
[HTML][HTML] Pros and cons of adenovirus-based SARS-CoV-2 vaccines
EJ Kremer - Molecular Therapy, 2020 - cell.com
Most of us might be surprised by the rudimentary scientific rationale prevalent in the field of
vaccine research just 50 years ago. For over a century after Louis Pasteur's vaccine against …
vaccine research just 50 years ago. For over a century after Louis Pasteur's vaccine against …
Non-viral COVID-19 vaccine delivery systems
The novel corona virus termed severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of …
CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of …
Complete protection of nasal and lung airways against SARS-CoV-2 challenge by antibody plus Th1 dominant N-and S-specific T-cell responses to subcutaneous …
E Gabitzsch, JT Safrit, M Verma, A Rice, P Sieling… - bioRxiv, 2020 - biorxiv.org
Background To address the dire need for a safe and effective vaccine to protect individuals
from and reduce transmission of SARS-CoV-2, we developed a COVID-19 vaccine that …
from and reduce transmission of SARS-CoV-2, we developed a COVID-19 vaccine that …
Inhalable vaccines: Can they help control pandemics?
The emergence of a new coronavirus presents a huge risk to public health worldwide and
has spread widely amongst the human population. Since its emergence, the severe acute …
has spread widely amongst the human population. Since its emergence, the severe acute …
An intranasal live-attenuated SARS-CoV-2 vaccine limits virus transmission
JM Adler, R Martin Vidal, C Langner… - Nature …, 2024 - nature.com
The development of effective SARS-CoV-2 vaccines has been essential to control COVID-
19, but significant challenges remain. One problem is intramuscular administration, which …
19, but significant challenges remain. One problem is intramuscular administration, which …
A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects …
PA Ilinykh, S Periasamy, K Huang, NA Kuzmina… - npj Vaccines, 2022 - nature.com
Respiratory tract vaccination has an advantage of needle-free delivery and induction of
mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human …
mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human …