Oral and intranasal vaccines against SARS‐CoV‐2: Current progress, prospects, advantages, and challenges

S Kar, P Devnath, TB Emran, TE Tallei… - Immunity …, 2022 - Wiley Online Library
Background The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has
caused a deadly pandemic in the 21st century, resulting in many deaths, economic loss, and …

ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination

M Cokarić Brdovčak, J Materljan… - European journal of …, 2022 - Wiley Online Library
COVID‐19 vaccines prevent severe forms of the disease, but do not warrant complete
protection against breakthrough infections. This could be due to suboptimal mucosal …

Intranasal single-replication influenza vector induces cross-reactive serum and mucosal antibodies against SARS-CoV-2 variants

MJ Moser, L Hill-Batorski, RA Bowen, SM Matejka… - Vaccines, 2023 - mdpi.com
Current SARS-CoV-2 vaccines provide protection for COVID-19-associated hospitalization
and death, but remain inefficient at inhibiting initial infection and transmission. Despite …

Safety, tolerability, and immunogenicity of an aerosolised adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in adults: preliminary report of an open-label …

S Wu, J Huang, Z Zhang, J Wu, J Zhang… - The Lancet Infectious …, 2021 - thelancet.com
Background SARS-CoV-2 has caused millions of deaths, and, since Aug 11, 2020, 20
intramuscular COVID-19 vaccines have been approved for use. We aimed to evaluate the …

Recent advances in respiratory immunization: A focus on COVID-19 vaccines

X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …

[HTML][HTML] A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

TL Bricker, TL Darling, AO Hassan, HH Harastani… - Cell reports, 2021 - cell.com
The development of an effective vaccine against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19) …

Towards the future exploration of mucosal mRNA vaccines against emerging viral diseases; lessons from existing next-generation mucosal vaccine strategies

SA Hameed, S Paul, GKY Dellosa, D Jaraquemada… - npj Vaccines, 2022 - nature.com
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19
pandemic owing to rapid development, effectiveness, and scalability to meet the global …

The rise of vectored vaccines: a legacy of the COVID-19 global crisis

DSO Daian e Silva, FG da Fonseca - Vaccines, 2021 - mdpi.com
The COVID-19 pandemic represents a milestone in vaccine research and development in a
global context. A worldwide effort, as never seen before, involved scientists from all over the …

Viral vector vaccine development and application during the COVID-19 pandemic

S Deng, H Liang, P Chen, Y Li, Z Li, S Fan, K Wu, X Li… - Microorganisms, 2022 - mdpi.com
With the accumulation of mutations in SARS-CoV-2 and the continuous emergence of new
variants, the importance of developing safer and effective vaccines has become more …

Are genetic vaccines the right weapon against COVID-19?

A Conforti, E Marra, G Roscilli, F Palombo, G Ciliberto… - Molecular Therapy, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
Coronavirus disease (COVID-19), emerged in China in December 2019. Investigators have …