Broad-spectrum vaccine via combined immunization routes triggers potent immunity to SARS-CoV-2 and its variants

M Xing, Y Wang, X Wang, J Liu, W Dai, G Hu… - Journal of …, 2023 - Am Soc Microbiol
Developing broad-spectrum vaccines and optimal vaccination strategies is crucial to
controlling the COVID-19 pandemic. Here, we generated a chimpanzee adenoviral vector …

Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2

MDJ Dicks, LM Rose, RA Russell, LAH Bowman… - Molecular Therapy, 2022 - cell.com
Adenovirus vector vaccines have been widely and successfully deployed in response to
coronavirus disease 2019 (COVID-19). However, despite inducing potent T cell immunity …

A scalable topical vectored vaccine candidate against SARS-CoV-2

MA Rohaim, M Munir - Vaccines, 2020 - mdpi.com
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) caused an ongoing
unprecedented global public health crises of coronavirus disease in 2019 (CoVID-19). The …

[HTML][HTML] A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

J Chen, P Wang, L Yuan, L Zhang, L Zhang, H Zhao… - Science bulletin, 2022 - Elsevier
Remarkable progress has been made in developing intramuscular vaccines against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with …

Harnessing cellular immunity for vaccination against respiratory viruses

NW Lukacs, CA Malinczak - Vaccines, 2020 - mdpi.com
Severe respiratory viral infections, such as influenza, metapneumovirus (HMPV), respiratory
syncytial virus (RSV), rhinovirus (RV), and coronaviruses, including severe acute respiratory …

Oral and intranasal Ad5 SARS-CoV-2 vaccines decrease disease and viral transmission in a golden hamster model

SN Langel, S Johnson, CI Martinez, SN Tedjakusuma… - BioRxiv, 2021 - biorxiv.org
Transmission-blocking strategies that slow the spread of SARS-CoV-2 and protect against
COVID-19 are needed. We have developed a shelf-stable, orally-delivered Ad5-vectored …

Do we need nasal vaccines against COVID 19 to suppress the transmission of infections?

H Brüssow - Microbial Biotechnology, 2023 - Wiley Online Library
Covid‐19 vaccines have within the first year prevented about 14 million deaths but did not
induce a strong mucosal immune response. Data from US, UK, Singapore and Israel …

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Z Wang, KD Popowski, D Zhu… - Nature biomedical …, 2022 - nature.com
The first two mRNA vaccines against infection by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) that were approved by regulators require a cold chain and …

Vaccines against COVID-19: priority to mRNA-based formulations

S Pascolo - Cells, 2021 - mdpi.com
As of September 2021, twenty-one anti-COVID-19 vaccines have been approved in the
world. Their utilization will expedite an end to the current pandemic. Besides the usual …

Artificial cell membrane polymersome-based intranasal beta spike formulation as a second generation COVID-19 vaccine

JH Lam, D Shivhare, TW Chia, SL Chew, G Sinsinbar… - ACS …, 2022 - ACS Publications
Current parenteral coronavirus disease 2019 (Covid-19) vaccines inadequately protect
against infection of the upper respiratory tract. Additionally, antibodies generated by wild …