In ischemic stroke (IS) impairment of the blood–brain barrier (BBB) has an important role in
the secondary deterioration of neurological function. BBB disruption is associated with …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …

NLRP3 inflammasome is a key mediator in ischemic stroke-induced neuroinflammation and
subsequent brain injury. Our previous study demonstrated the potent activity of Pien-Tze …

MicroRNAs play an essential role in stroke pathology. Here, we investigated the role of a
newly identified microRNA, miR-3473b, in stroke pathology. The expression of miR-3473b …

There is no effective therapy for intracerebral hemorrhage (ICH) because of poor
understanding of the mechanisms of brain injury after hemorrhage. The NLRP3 …

The nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing
protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic …

Abstract Blocking TLR4/peroxiredoxin (Prx6) signaling is proposed to be a novel therapeutic
strategy for ischemic stroke because extracellular Prx6 released from ischemic cells may act …

The inflammatory response in the cerebral cortex serves an important role in the progression
of secondary injury following traumatic brain injury (TBI). The NLR family pyrin domain …

Acute ischemic stroke (AIS), one of the leading causes of mortality worldwide, is
characterized by a rapid inflammatory cascade resulting in exacerbation of ischemic brain …

Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …