Liquid biopsies: DNA methylation analyses in circulating cell-free DNA

H Zeng, B He, C Yi, J Peng - Journal of genetics and genomics, 2018 - Elsevier
Abstract Analysis of patient's materials like cells or nucleic acids obtained in a minimally
invasive or noninvasive manner through the sampling of blood or other body fluids serves as …

[HTML][HTML] Cell-free DNA methylation profiling analysis—technologies and bioinformatics

J Huang, L Wang - Cancers, 2019 - mdpi.com
Analysis of circulating nucleic acids in bodily fluids, referred to as “liquid biopsies”, is rapidly
gaining prominence. Studies have shown that cell-free DNA (cfDNA) has great potential in …

DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer

J Wang, X Han, Y Sun - Science China Life Sciences, 2017 - Springer
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could
serve as a “liquid biopsy”, which would be useful for numerous diagnostic applications …

[HTML][HTML] Epigenetic biomarkers in cell-free DNA and applications in liquid biopsy

W Gai, K Sun - Genes, 2019 - mdpi.com
Cell-free circulating DNA (cfDNA) in plasma has gained global interest as a diagnostic
material for noninvasive prenatal testing and cancer diagnosis, or the so-called “liquid …

Liquid biopsy of methylation biomarkers in cell-free DNA

H Luo, W Wei, Z Ye, J Zheng, R Xu - Trends in molecular medicine, 2021 - cell.com
Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …

[HTML][HTML] Computational challenges in detection of cancer using cell-free DNA methylation

M Sharma, RK Verma, S Kumar, V Kumar - Computational and Structural …, 2022 - Elsevier
Cell-free DNA (cfDNA) methylation profiling is considered promising and potentially reliable
for liquid biopsy to study progress of diseases and develop reliable and consistent …

Methylation in cell-free DNA for early cancer detection

FF de la Cruz, RB Corcoran - Annals of Oncology, 2018 - annalsofoncology.org
Liquid biopsies and, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising and potentially transformative non-invasive diagnostic approach in oncology [1 …

[HTML][HTML] Detection of cell types contributing to cancer from circulating, cell-free methylated DNA

ME Barefoot, N Loyfer, AJ Kiliti, AP McDeed IV… - Frontiers in …, 2021 - frontiersin.org
Detection of cellular changes in tissue biopsies has been the basis for cancer diagnostics.
However, tissue biopsies are invasive and limited by inaccuracies due to sampling …

Methylation extends the reach of liquid biopsy in cancer detection

W Li, XJ Zhou - Nature Reviews Clinical Oncology, 2020 - nature.com
Measuring the methylation status of cell-free DNA (cfDNA) in plasma holds great potential
for the early, noninvasive detection of cancer. Two recent papers published in Nature …

[HTML][HTML] Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA

MA Kerachian, M Azghandi, S Mozaffari-Jovin… - Clinical …, 2021 - Springer
Methylation analysis of circulating cell-free DNA (cirDNA), as a liquid biopsy, has a
significant potential to advance the detection, prognosis, and treatment of cancer, as well as …