The transcription factor AP-1 (activator protein-1) is involved in cellular proliferation,
transformation and death. Using mice and cells lacking AP-1 components, the target-genes …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

Since its discovery more than two decades ago the involvement of the Activating protein 1
(AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound …

The AP-1 transcription factor is composed of a mixture of homo-and hetero-dimers formed
between Jun and Fos proteins. The different Jun and Fos family members vary significantly …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

c-Jun, a signal-transducing transcription factor of the AP-1 family, normally implicated in cell
cycle progression, differentiation and cell transformation, recently has also been linked to …

The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …

Abstract c-Jun activation by mitogen-activated protein kinases has been implicated in
various cellular signal responses. We investigated how JNK and c-Jun contribute to …

RECENT advances indicate a link between tumour promoters, transformation, and AP-1
activity1. Protein kinase C activation increases AP-1 DNA-binding activity independently of …

This issue attempts to give a 'state of the art'overview of the AP-1 transcription factor family, a
fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP …