Physically distinct cholesterol/sphingolipid-rich plasma membrane microdomains, so-called
lipid rafts, have been recognized to play an important regulatory role in various cellular …

Here we show that activated Th1 and Th2 cells have distinct patterns of membrane
compartmentalization into lipid rafts. TCR complex members are recruited efficiently to rafts …

The plasma membranes of eukaryotic cells are not uniform and possess distinct cholesterol–
and sphingolipid–rich raft microdomains that are enriched in proteins known to be essential …

A key question in understanding the functional role of lipid rafts is whether lipid
microdomains at the plasma membrane outer leaflet are coupled to lipid microdomains at …

Activating stimuli for T lymphocytes are transmitted through plasma membrane domains that
form at T‐cell antigen receptor (TCR) signalling foci. Here, we determined the molecular …

The current model suggesting that raft integrity is required for T cell activation is mostly (but
not exclusively) based on the use of drugs, such as methyl‐β‐cyclodextrin (Mβ CD), that …

Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological
responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as …

Glycolipid-enriched membrane microdomains (“rafts”) are critical sites for signal transduction
and other processes such as intracellular transport. While the participation of T-cell rafts in …

There is now considerable evidence suggesting that the plasma membrane of mammalian
cells is compartmentalized by functional lipid raft microdomains. These structures are …

Plasma membranes of eukaryotic cells are not uniform, possessing distinct cholesterol-and
sphingolipid-rich lipid raft microdomains which constitute critical sites for signal transduction …