Novel 2019 coronavirus: Genome structure, clinical trials, and outstanding questions

MP Jogalekar, A Veerabathini… - … Biology and Medicine, 2020 - journals.sagepub.com
Novel 2019 coronavirus has created havoc across the globe since its emergence in
December 2019 in Wuhan, China, and fast spreading potential. While we were able to …

[HTML][HTML] After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …

Potential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements

A Pandey, AN Nikam, AB Shreya, SP Mutalik… - Life sciences, 2020 - Elsevier
The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal
with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is …

[HTML][HTML] SARS-CoV-2 pathophysiology and assessment of coronaviruses in CNS diseases with a focus on therapeutic targets

J Vallamkondu, A John, WY Wani, SP Ramadevi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The novel Coronavirus disease of 2019 (nCOV-19) is a viral outbreak noted first in Wuhan,
China. This disease is caused by Severe Acute Respiratory Syndrome (SARS) Coronavirus …

An overview of human proteins and genes involved in SARS-CoV-2 infection

Z Jahanafrooz, Z Chen, J Bao, H Li, L Lipworth, X Guo - Gene, 2022 - Elsevier
As of July 2021, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-
CoV-2, has led to more than 200 million infections and more than 4.2 million deaths globally …

[HTML][HTML] A structural view of the SARS-CoV-2 virus and its assembly

NJ Hardenbrook, P Zhang - Current opinion in virology, 2022 - Elsevier
Highlights•Structural biology plays a vital role in SARS-CoV-2 vaccine and treatment.•High-
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …

[HTML][HTML] SARS-CoV-2 nsp1: bioinformatics, potential structural and functional features, and implications for drug/vaccine designs

YQ Min, Q Mo, J Wang, F Deng, H Wang… - Frontiers in …, 2020 - frontiersin.org
The emerging coronavirus disease (COVID-19) caused by SARS-CoV-2 has led to social
and economic disruption globally. It is urgently needed to understand the structure and …

[HTML][HTML] SARS-CoV-2 and emerging variants: unmasking structure, function, infection, and immune escape mechanisms

J Li, H Jia, M Tian, N Wu, X Yang, J Qi… - Frontiers in Cellular …, 2022 - frontiersin.org
As of April 1, 2022, over 468 million COVID-19 cases and over 6 million deaths have been
confirmed globally. Unlike the common coronavirus, SARS-CoV-2 has highly contagious …

[HTML][HTML] Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

[HTML][HTML] The human coronavirus disease COVID-19: its origin, characteristics, and insights into potential drugs and its mechanisms

L Alanagreh, F Alzoughool, M Atoum - Pathogens, 2020 - mdpi.com
The emerging coronavirus disease (COVID-19) swept across the world, affecting more than
200 countries and territories. Genomic analysis suggests that the COVID-19 virus originated …