NT‐3‐mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo
S Kumar, MA Kahn, L Dinh… - Journal of neuroscience …, 1998 - Wiley Online Library
We have previously described the expression of a functional full‐length trkC transcript for
neurotrophin‐3 (NT‐3) receptor in oligodendroglia (OL) cells (Kumar and de Vellis, 1996) …
neurotrophin‐3 (NT‐3) receptor in oligodendroglia (OL) cells (Kumar and de Vellis, 1996) …
Neurotrophin activates signal transduction in oligodendroglial cells: Expression of functional TrkC receptor isoforms
S Kumar, J De Vellis - Journal of neuroscience research, 1996 - Wiley Online Library
The role of the NT‐3 has been implicated in the survival of progenitor oligodendrocytes in
culture. The object of this study was to investigate the expression of the TrkC receptor and its …
culture. The object of this study was to investigate the expression of the TrkC receptor and its …
Neurotrophin‐3 and brain‐derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons
HN Marsh, HC Palfrey - Journal of neurochemistry, 1996 - Wiley Online Library
Expression of the neurotrophin‐3 (NT‐3) receptor (TrkC) and the effects of NT‐3 on signal
transduction were investigated in highly enriched populations of embryonic rat hippocampal …
transduction were investigated in highly enriched populations of embryonic rat hippocampal …
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
F Lamballe, R Klein, M Barbacid - Cell, 1991 - cell.com
We report the isolation and molecular characterization of t&C, a new member of the trk family
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …
trkC encodes multiple neurotrophin‐3 receptors with distinct biological properties and substrate specificities.
F Lamballe, P Tapley, M Barbacid - The EMBO Journal, 1993 - embopress.org
The trkC gene product gp145trkC is a high affinity signaling receptor for neurotrophin‐3 (NT‐
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
3), a member of the NGF family of neurotrophic factors. We now report that trkC encodes at …
Mice lacking NT‐3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells
Abstract Neurotrophin‐3 (NT‐3) and its receptor TrkC are known to be important for
neuronal survival. More recently, NT‐3 has been implicated as playing a role in …
neuronal survival. More recently, NT‐3 has been implicated as playing a role in …
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells
P Tsoulfas, D Soppet, E Escandon, L Tessarollo… - Neuron, 1993 - cell.com
Members of the Trk tyrosine kinase family have recently been identified as functional
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …
Neurotrophin signal transduction by the Trk receptor
DR Kaplan, RM Stephens - Journal of neurobiology, 1994 - Wiley Online Library
The initial event in the neuronal differentiation of PC12 cells is the binding of the
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …
Induction of a distinct morphology and signal transduction in TrkB/PC12 cells by nerve growth factor and brain‐derived neurotrophic factor
Y Iwasaki, M Ishikawa, N Okada… - Journal of …, 1997 - Wiley Online Library
A clonal cell line stably expressing trkB (TrkB/PC12) was established from rat
pheochromocytoma PC12 cells. Brain‐derived neurotrophic factor (BDNF), as well as nerve …
pheochromocytoma PC12 cells. Brain‐derived neurotrophic factor (BDNF), as well as nerve …
Selective regulation of trkC expression by NT3 in the developing peripheral nervous system
S Wyatt, G Middleton, E Doxakis… - Journal of …, 1999 - Soc Neuroscience
We have studied the influence of neurotrophin-3 (NT3) on the expression of its receptor
tyrosine kinase, trkC, in embryonic mice. The expression of trkC transcripts encoding full …
tyrosine kinase, trkC, in embryonic mice. The expression of trkC transcripts encoding full …