The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

G Wen, T Zhou, W Gu - Protein & cell, 2021 - academic.oup.com
Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies

S Wang, K Zhang, S Tan, J Xin, Q Yuan, H Xu, X Xu… - Molecular cancer, 2021 - Springer
Cancer is a leading cause of death worldwide, particularly because of its high mortality rate
in patients who are diagnosed at late stages. Conventional biomarkers originating from …

Circular RNAs: from biogenesis and function to diseases

D Li, Y Yang, ZQ Li, LC Li, XH Zhu - Chinese Medical Journal, 2019 - journals.lww.com
Objective: Evidence suggests that various diseases may contribute to the circular RNAs
(circRNAs) expression disorder. This review was aimed at looking for appropriate …

Circular RNAs: promising biomarkers for human diseases

Z Zhang, T Yang, J Xiao - EBioMedicine, 2018 - thelancet.com
Circular RNA (circRNA) is a group of endogenous noncoding RNA characterized by a
covalently closed cyclic structure lacking poly-adenylated tails. Recent studies have …

Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection

WB Yin, MG Yan, X Fang, JJ Guo, W Xiong… - Clinica chimica acta, 2018 - Elsevier
Abstract Background Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs)
and characterized by covalently closed loop without 5′ and 3′ end. Recently, the …

circRNAs signature as potential diagnostic and prognostic biomarker for diabetes mellitus and related cardiovascular complications

M Zaiou - Cells, 2020 - mdpi.com
Circular RNAs (circRNAs) belong to the ever-growing class of naturally occurring noncoding
RNAs (ncRNAs) molecules. Unlike linear RNA, circRNAs are covalently closed transcripts …

Circular RNA: an emerging non-coding RNA as a regulator and biomarker in cancer

B Chen, S Huang - Cancer letters, 2018 - Elsevier
Circular RNA (circRNA) is a type of covalently closed non-coding RNA that may regulate
gene expression in eukaryotes. The recent application of high-throughput RNA sequencing …

[HTML][HTML] Circular RNAs: regulators of cancer-related signaling pathways and potential diagnostic biomarkers for human cancers

Z Yang, L Xie, L Han, X Qu, Y Yang, Y Zhang, Z He… - Theranostics, 2017 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are newly discovered endogenous non-coding RNAs featuring
structural stability, high abundance, and tissue-specific expression. CircRNAs are prevalent …

Circular RNA expression profiles and features in human tissues: a study using RNA-seq data

T Xu, J Wu, P Han, Z Zhao, X Song - BMC genomics, 2017 - Springer
Abstract Background Circular RNA (circRNA) is one type of noncoding RNA that forms a
covalently closed continuous loop. Similar to long noncoding RNA (lncRNA), circRNA can …

Identification and characterization of circular RNAs as a new class of putative biomarkers in human blood

S Memczak, P Papavasileiou, O Peters, N Rajewsky - PloS one, 2015 - journals.plos.org
Covalently closed circular RNA molecules (circRNAs) have recently emerged as a class of
RNA isoforms with widespread and tissue specific expression across animals, oftentimes …