The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

Circadian rhythms are fundamental biological systems in most organisms. Epidemiological
and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor …

The circadian rhythm is generated at the cellular level by a molecular clock system that
involves specific genes. Studies have revealed that circadian clock disruption is a control …

Recent studies have demonstrated the influence of clock genes in cell cycle regulation, cell
proliferation, apoptosis and DNA damage recognition and repair. There is evidence …

Recent studies have shown that disruption of the circadian rhythm was one of the
endogenous factors contributing to tumorigenesis of various human malignancies, including …

Circadian rhythm describes the 24-h oscillation in physiology and behavior of living
organisms and presents a timing controller for life activity. Studies in recent years have …

Circadian rhythms are daily oscillations in various biological processes, generated by the
feedback loops of eight core circadian genes: Period1 (Per1), Period2 (Per2), Period3 …

Abstract Background and Objectives The circadian rhythm regulates the cell cycle
progression and DNA damage response. The aim of our study was to investigate the …

Colorectal cancer is the most prevalent among digestive system cancers. Carcinogenesis
relies on disrupted control of cellular processes, such as metabolism, proliferation, DNA …

Introduction The circadian rhythm is responsible for physiologic homeostasis, behavior, and
components of multiple metabolic processes. Disruption of the circadian rhythm is …