N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases

C Kaya, J Konstantinović, AM Kany… - Journal of Medicinal …, 2022 - ACS Publications
Drug-resistant pathogens pose a global challenge to public health as they cause diseases
that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc …

[HTML][HTML] Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance

JL Kurz, MM Pedroso, E Richard, RP McGeary… - Bioorganic & Medicinal …, 2023 - Elsevier
Abstract Metallo-β-lactamases (MBLs) are a group of Zn (II)-dependent enzymes that pose a
major threat to global health. They are linked to an increasing number of multi-drug resistant …

Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-β-lactamase inhibitors

YH Yan, HS Ding, KR Zhu, BS Mu, Y Zheng… - European Journal of …, 2023 - Elsevier
The emergence of metallo-β-lactamases (MBLs) confers resistance to nearly all the β-lactam
antibiotics, including carbapenems. Currently, there is a lack of clinically useful MBL …

Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition

N Wade, KHME Tehrani, NC Brüchle… - …, 2021 - Wiley Online Library
Abstract Metallo‐β‐lactamases (MBLs) are zinc‐dependent bacterial enzymes that
inactivate essentially all classes of β‐lactam antibiotics including last‐resort carbapenems …

Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-β-Lactamase Inhibitors

R Li, H Su, W Chen, YH Yan, C Zhou, L Mou… - Bioorganic & Medicinal …, 2022 - Elsevier
As one of important mechanisms to β-lactam antimicrobial resistance, metallo-β-lactamases
(MBLs) have been receiving increasing worldwide attentions. Ambler subclass B1 MBLs are …

Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes

V Villamil, MA Rossi, MF Mojica… - Journal of Medicinal …, 2024 - ACS Publications
Antimicrobial resistance is a global public health threat. Metallo-β-lactamases (MBLs)
inactivate β-lactam antibiotics, including carbapenems, are disseminating among Gram …

An updated patent review of metallo-β-lactamase inhibitors (2020–2023)

E Denakpo, T Naas, BI Iorga - Expert Opinion on Therapeutic …, 2023 - Taylor & Francis
ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …

Discovery of 2-aminothiazole-4-carboxylic acids as broad-spectrum metallo-β-lactamase inhibitors by mimicking carbapenem hydrolysate binding

YH Yan, TT Zhang, R Li, SY Wang, LL Wei… - Journal of Medicinal …, 2023 - ACS Publications
Metallo-β-lactamases (MBLs) are zinc-dependent enzymes capable of hydrolyzing all
bicyclic β-lactam antibiotics, posing a great threat to public health. However, there are …

Fragment‐based screening and hit‐based substructure search: Rapid discovery of 8‐hydroxyquinoline‐7‐carboxylic acid as a low‐cytotoxic, nanomolar metallo β …

WS Shin, ME Nguyen, A Bergstrom… - Chemical Biology & …, 2021 - Wiley Online Library
Abstract Metallo‐β–lactamases (MBLs) are zinc‐containing carbapenemases that inactivate
a broad range of β–lactam antibiotics. There is a lack of β–lactamase inhibitors for restoring …

The development of new small-molecule inhibitors targeting bacterial metallo-β-lactamases

P Wang, J Cheng, CC Liu, K Tang, F Xu… - Current Topics in …, 2018 - ingentaconnect.com
Metallo-β-lactamases (MBLs) are a family of Zn (II)-dependent enzymes that can hydrolyze
almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram …