A probable role for IFN-γ in the development of a lung immunopathology in SARS

M Theron, KJ Huang, YW Chen, CC Liu, HY Lei - Cytokine, 2005 - Elsevier
Recent work carried out in our laboratory showed the existence of a cytokine storm in SARS
patients, dominated by Th1-type mediators. We thus hypothesized that IFN-γ may play a …

[HTML][HTML] ARDS in SARS: cytokine mediators and treatment implications

M Salto-Tellez, E Tan, B Lim - Cytokine, 2005 - ncbi.nlm.nih.gov
We wish to draw the reader's attention to the possibility that the severe pulmonary failure in
severe adult respiratory syndrome (SARS), associated with a mortality rate of 15e20%, may …

An interferon‐γ‐related cytokine storm in SARS patients

KJ Huang, IJ Su, M Theron, YC Wu… - Journal of medical …, 2005 - Wiley Online Library
Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute
respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL …

Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome

JY CHIEN, PR HSUEH, WC CHENG, CJ YU… - …, 2006 - Wiley Online Library
Objective and background: Pathological changes in severe acute respiratory syndrome
(SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and …

Analysis of serum cytokines in patients with severe acute respiratory syndrome

Y Zhang, J Li, Y Zhan, L Wu, X Yu, W Zhang… - Infection and …, 2004 - Am Soc Microbiol
Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory
system. Although a novel coronavirus has been identified as the causative agent of SARS …

SARS: clinical virology and pathogenesis

J Nicholls, XP DONG, G Jiang, M Peiris - Respirology, 2003 - Wiley Online Library
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, called the
SARS coronavirus (SARS‐CoV). Over 95% of well characterized cohorts of SARS have …

Cytokine regulation in SARS coronavirus infection compared to other respiratory virus infections

T Okabayashi, H Kariwa, S Yokota, S Iki… - Journal of medical …, 2006 - Wiley Online Library
The pathogenesis of severe acute respiratory syndrome (SARS) is poorly understood and
cytokine dysregulation has been suggested as one relevant mechanism to be explored. We …

Multiple organ infection and the pathogenesis of SARS

J Gu, E Gong, B Zhang, J Zheng, Z Gao… - The Journal of …, 2005 - rupress.org
After> 8,000 infections and> 700 deaths worldwide, the pathogenesis of the new infectious
disease, severe acute respiratory syndrome (SARS), remains poorly understood. We …

Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome

Y Jiang, J Xu, C Zhou, Z Wu, S Zhong, J Liu… - American journal of …, 2005 - atsjournals.org
Rationale: There is currently no optimal treatment or effective drug for severe acute
respiratory syndrome (SARS), because the immunopathologic mechanism is poorly …

SARS spike protein induces phenotypic conversion of human B cells to macrophage-like cells

SF Chiang, TY Lin, KC Chow, SH Chiou - Molecular immunology, 2010 - Elsevier
Massive aggregations of macrophages are frequently detected in afflicted lungs of patients
with severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. In …