Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
Immune cells secrete small protein molecules that aim for cell–cell communications. These
small molecules are called cytokines. Targeting cancer cells with administration of bispecific …

The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Cytokine storms in infectious diseases

JR Teijaro - Seminars in immunopathology, 2017 - Springer
The term Bcytokine storm^ has been adopted in the past several decades as a phrase to
describe the aberrant production of soluble mediators and the accompanying …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

[HTML][HTML] The immunology of macrophage activation syndrome

CB Crayne, S Albeituni, KE Nichols… - Frontiers in …, 2019 - frontiersin.org
Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …

Cytokine storm

DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

Clinical implications of dysregulated cytokine production

MK Slifka, JL Whitton - Journal of molecular medicine, 2000 - Springer
Cytokines are soluble proteins that are produced and secreted as part of the immune
response to a variety of tissue insults including infection, cancer, and autoimmunity. Most …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

A Fara, Z Mitrev, RA Rosalia, BM Assas - Open biology, 2020 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in
the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; …