Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate …

Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …

Kidney diseases manifest in progressive loss of renal function, which ultimately leads to
complete kidney failure. The mechanisms underlying the origins and progression of kidney …

There have been tremendous advances during the last decade in methods for large-scale,
high-throughput data generation and in novel computational approaches to analyze these …

Despite advancements in standardizing the criteria for acute kidney injury (AKI), its definition
remains based on changes in serum creatinine and urinary output that do not specifically …

Acute kidney injury (AKI) is defined as a decrease in kidney function within hours, which
encompasses both injury and impairment of renal function. AKI is not considered a …

Comprehensive and spatially mapped molecular atlases of organs at a cellular level are a
critical resource to gain insights into pathogenic mechanisms and personalized therapies for …

Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

In this review of the application of proteomics and metabolomics to kidney disease research,
we review key concepts, highlight illustrative examples, and outline future directions. The …

An incomplete understanding of the biology of the human kidney, including the relative
abundances of and interactions between intrinsic and immune cells, has long constrained …