The astonishing array of cellular phenotypes required to make a complex organism such as
a human is generated from an identical genetic sequence in the nucleus of each cell. The …

Building a brain is complicated but maintaining one may be an even greater challenge.
Epigenetic mechanisms, including DNA methylation, histone and chromatin modifications …

It is becoming increasingly clear that epigenetic modifications are critical factors in the
regulation of gene expression. With regard to the nervous system, epigenetic alterations …

Two major environmental developments have occurred in mammalian evolution which have
impacted on the genetic and epigenetic regulation of brain development. The first of these …

The role of epigenetic molecular mechanisms in regulation of CNS function is one of the
most exciting areas of contemporary molecular neuroscience. This emerging field, variously …

The transcriptional programs of neural progenitor cells change dynamically during
neurogenesis, a process regulated by both intrinsic and extrinsic factors. Although many of …

The epigenome controls all aspect of eukaryotic development as the packaging of DNA
greatly affects gene expression. Epigenetic changes are reversible and do not affect the …

Epigenetics control the gene expression program and cellular identity of individual cells in
our body via molecular mechanisms that are not directly reflected by the genomic DNA [1] …

Epigenetic mechanisms regulate cellular identity and organ morphology via controlling the
gene expression program of specific cell types. Such mechanisms are not directly controlled …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …