Fungal secondary metabolites (SMs) represent an invaluable source of therapeutic drugs.
Genomics-based approaches to SM discovery have revealed a vast and largely untapped …

Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …

Fungi are prolific producers of natural products, compounds which have had a large societal
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …

Recent advancements in genome sequencing and bioinformatic analysis of fungal genomes
have revealed that fungi possess cryptic or silent biosynthetic gene clusters (BGCs). This …

Fungal secondary metabolites (SMs) are currently an important source of medically useful
compounds, and sequencing projects have revealed that fungi have many clusters of genes …

Fungi produce an impressive array of secondary metabolites (SMs) including mycotoxins,
antibiotics and pharmaceuticals. The genes responsible for their biosynthesis, export, and …

Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small,
bioactive molecules not required for growth but which are essential to their ecological …

Genomics has revolutionized the research on fungal secondary metabolite (SM)
biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the …

The genomes of filamentous fungi contain up to 90 biosynthetic gene clusters (BGCs)
encoding diverse secondary metabolites—an enormous reservoir of untapped chemical …

Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …