Inhibition of PI3K/AKT signaling using BKM120 reduced the proliferation and migration potentials of colorectal cancer cells and enhanced cisplatin-induced …
Background Although extensive efforts have been made to improve the treatment of
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
colorectal cancer (CRC) patients, the prognosis for these patients remains poor. A wide …
A novel small-molecule PI3K/Akt signaling inhibitor, W934, exhibits potent antitumor efficacy in A549 non-small-cell lung cancer
J Wang, HY Wang, Y Shen, D Liang, HY Wang… - Anti-cancer …, 2019 - journals.lww.com
Small-molecule targeted antitumor drugs are considered to be a promising treatment that
can improve the efficacy and reduce side effects. PI3K/Akt signaling pathway is constantly …
can improve the efficacy and reduce side effects. PI3K/Akt signaling pathway is constantly …
PI3K-Akt signaling pathway and chemotherapy drug resistance in cancer
P Jiang, B Chang - Journal of International Oncology, 2014 - pesquisa.bvsalud.org
ABSTRACT PI3K-Akt signaling pathway plays a critical role in the regulation of cell
proliferation, differentiation and apoptosis, and is closely related to the physiological function …
proliferation, differentiation and apoptosis, and is closely related to the physiological function …
Selective PI3K inhibition by BKM120 and BEZ235 alone or in combination with chemotherapy in wild-type and mutated human gastrointestinal cancer cell lines
A Mueller, E Bachmann, M Linnig… - Cancer chemotherapy …, 2012 - Springer
Purpose New targeted agents like antibodies or small molecules against tyrosine and lipid
kinases clearly expand the standard therapy options in oncology. However, tumour …
kinases clearly expand the standard therapy options in oncology. However, tumour …
[HTML][HTML] ZDQ-0620, a novel phosphatidylinositol 3-kinase inhibitor, inhibits colorectal carcinoma cell proliferation and suppresses angiogenesis by attenuating PI3K …
X Qin, M Liu, C Xu, B Xing, X Xu, Y Wu, H Ding… - Frontiers in …, 2022 - frontiersin.org
The PI3K/AKT pathway plays a central role in human cancers, aberrant activation of this
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
pathway is associated with tumorigenesis, cancer progression and angiogenesis. Based on …
Targeted inhibition of the phosphoinositide 3-kinase impairs cell proliferation, survival, and invasion in colon cancer
F Yang, JY Gao, H Chen, ZH Du, XQ Zhang… - OncoTargets and …, 2017 - Taylor & Francis
Background Colon cancer is the third most common cancer in the world, and its metastasis
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
and drug resistance are challenging for its effective treatment. The PI3K/Akt/mTOR pathway …
[HTML][HTML] β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
S Nie, L Chang, Y Huang, H Zhou, Q Yang… - Natural Products and …, 2024 - Springer
Abstract Phosphoinositide 3-kinase (PI3Ks) are lipid kinases widely involved in cell
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
proliferation, metastasis and differentiation. Constitutive activation of the PI3K/Akt/mTOR …
[HTML][HTML] Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
N Jiang, Q Dai, X Su, J Fu, X Feng, J Peng - Molecular biology reports, 2020 - Springer
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …
Design, synthesis and antitumor effects of novel benzimidazole derivatives as PI3K inhibitors
W Wu, S Li, J Chen, T Duo, C Ma - Bioorganic & Medicinal Chemistry …, 2023 - Elsevier
Abstract Blocking the PI3K/Akt pathway has been widely recognized as an attractive cancer
therapeutic strategy because of its crucial role in cell growth and survival. This study …
therapeutic strategy because of its crucial role in cell growth and survival. This study …
Exression and PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis
B Ye, LL Jiang, HT Xu, DW Zhou… - International journal of …, 2012 - journals.sagepub.com
Phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway plays a crucial
role in the formation and progression of many malignancies, and has been shown to be an …
role in the formation and progression of many malignancies, and has been shown to be an …