Coupling biomechanics to a cellular level model: an approach to patient-specific image driven multi-scale and multi-physics tumor simulation
CP May, E Kolokotroni, GS Stamatakos… - Progress in biophysics …, 2011 - Elsevier
Modeling of tumor growth has been performed according to various approaches addressing
different biocomplexity levels and spatiotemporal scales. Mathematical treatments range …
different biocomplexity levels and spatiotemporal scales. Mathematical treatments range …
A multiscale cell‐based model of tumor growth for chemotherapy assessment and tumor‐targeted therapy through a 3D computational approach
Objectives Computational modeling of biological systems is a powerful tool to clarify diverse
processes contributing to cancer. The aim is to clarify the complex biochemical and …
processes contributing to cancer. The aim is to clarify the complex biochemical and …
Towards the personalized treatment of glioblastoma: integrating patient-specific clinical data in a continuous mechanical model
MC Colombo, C Giverso, E Faggiano, C Boffano… - PLoS …, 2015 - journals.plos.org
Glioblastoma multiforme (GBM) is the most aggressive and malignant among brain tumors.
In addition to uncontrolled proliferation and genetic instability, GBM is characterized by a …
In addition to uncontrolled proliferation and genetic instability, GBM is characterized by a …
Evaluation of a mechanically coupled reaction–diffusion model for macroscopic brain tumor growth
The macroscopic growth of brain tumors has been studied by means of different
computational modeling approaches. Glioblastoma multiforme (GBM) is the most common …
computational modeling approaches. Glioblastoma multiforme (GBM) is the most common …
Towards model-based characterization of biomechanical tumor growth phenotypes
Gliomas are the most common malignant brain tumors in adults, with Glioblastoma (GBM)
being the most agressive subtype. GBM is clinically evaluated with magnetic resonance …
being the most agressive subtype. GBM is clinically evaluated with magnetic resonance …
Multiphysics modeling of reactions, mass transport and mechanics of tumor growth
The biochemical dynamics involved in tumor growth can be broadly classified into three
distinct spatial scales: the tumor scale, the cell-ECM interactions and the sub-cellular …
distinct spatial scales: the tumor scale, the cell-ECM interactions and the sub-cellular …
A fully coupled space–time multiscale modeling framework for predicting tumor growth
Most biological systems encountered in living organisms involve highly complex
heterogeneous multi-component structures that exhibit different physical, chemical, and …
heterogeneous multi-component structures that exhibit different physical, chemical, and …
Image-based biomarkers for engineering neuroblastoma patient-specific computational models
S Hervas-Raluy, D Sainz-DeMena… - Engineering with …, 2024 - Springer
Childhood cancer is a devastating disease that requires continued research and improved
treatment options to increase survival rates and quality of life for those affected. The …
treatment options to increase survival rates and quality of life for those affected. The …
[HTML][HTML] Non-operable glioblastoma: proposition of patient-specific forecasting by image-informed poromechanical model
We propose a novel image-informed glioblastoma mathematical model within a reactive
multiphase poromechanical framework. Poromechanics offers to model in a coupled manner …
multiphase poromechanical framework. Poromechanics offers to model in a coupled manner …
[HTML][HTML] A mechanobiological model for tumor spheroid evolution with application to glioblastoma: a continuum multiphysics approach
Background: Spheroids are in vitro quasi-spherical structures of cell aggregates, eventually
cultured within a hydrogel matrix, that are used, among other applications, as a …
cultured within a hydrogel matrix, that are used, among other applications, as a …