[HTML][HTML] An immune-based biomarker signature is associated with mortality in COVID-19 patients

MS Abers, OM Delmonte, EE Ricotta, J Fintzi, DL Fink… - JCI insight, 2021 - ncbi.nlm.nih.gov
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19) …

[HTML][HTML] IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19

M Luo, J Liu, W Jiang, S Yue, H Liu, S Wei - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Fatal cases of COVID-19 are increasing globally. We retrospectively
investigated the potential of immunologic parameters as early predictors of COVID-19 …

[HTML][HTML] Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

JG Wilson, LJ Simpson, AM Ferreira, A Rustagi… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …

[HTML][HTML] Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Y Zhao, L Qin, P Zhang, K Li, L Liang, J Sun, B Xu… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND. Identifying immune correlates of COVID-19 disease severity is an urgent
need for clinical management, vaccine evaluation, and drug development. Here, we present …

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

JS Lee, S Park, HW Jeong, JY Ahn, SJ Choi… - Science …, 2020 - science.org
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …

Upregulated type I interferon responses in asymptomatic COVID-19 infection are associated with improved clinical outcome

KI Masood, M Yameen, J Ashraf, S Shahid… - Scientific reports, 2021 - nature.com
Understanding key host protective mechanisms against SARS-CoV-2 infection can help
improve treatment modalities for COVID-19. We used a blood transcriptome approach to …

Age-severity matched cytokine profiling reveals specific signatures in Covid-19 patients

R Angioni, R Sanchez-Rodriguez, F Munari… - Cell death & …, 2020 - nature.com
A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity
has come out as a determinant for COVID-19 clinical outcomes, and several studies …

Blood interferon-α levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients

M Contoli, A Papi, L Tomassetti, P Rizzo… - Frontiers in …, 2021 - frontiersin.org
Background: Deficient interferon responses have been proposed as one of the relevant
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …

Longitudinal cytokine profile in patients with mild to critical COVID-19

L Ling, Z Chen, G Lui, CK Wong, WT Wong… - Frontiers in …, 2021 - frontiersin.org
The cytokine release syndrome has been proposed as the driver of inflammation in
coronavirus disease 2019 (COVID-19). However, studies on longitudinal cytokine profiles in …

COVID19 biomarkers: What did we learn from systematic reviews?

S Semiz - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID19) pandemic continues to represent a substantial
public health concern. It can rapidly progress to severe disease, with poor prognosis and a …