Correct and timely lineage decisions are critical for normal embryonic development and
homeostasis of adult tissues. Therefore, the search for fundamental principles that underlie …

Understanding how individual cells make fate decisions that lead to the faithful formation
and homeostatic maintenance of tissues is a fundamental goal of contemporary …

The concept of cell fate relates to the future identity of a cell, and its daughters, which is
obtained via cell differentiation and division. Understanding, predicting, and manipulating …

Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To …

Highlights•Single-cell atlases of mouse embryogenesis reveal epigenetic regulator
dynamics in early development.•Genetic perturbation in combination with single-cell …

The use of embryonic stem (ES) cells for generating healthy tissues has the potential to
revolutionize therapies for human disease or injury, for which there are currently no effective …

Transcriptional networks regulate cell fate decisions, which occur at the level of individual
cells. However, much of what we know about their structure and function comes from studies …

High‐throughput‐omics techniques have revolutionised biology, allowing for thorough and
unbiased characterisation of the molecular states of biological systems. However, cellular …

The complexity of gene regulatory networks that lead multipotent cells to acquire different
cell fates makes a quantitative understanding of differentiation challenging. Using a …

Mapping the paths that stem and progenitor cells take en route to differentiate and
elucidating the underlying molecular controls are key goals in developmental and stem cell …