Despite striking parallels between the fields of developmental biology and adult tissue
homeostasis, these are disconnected in contemporary research. Although development …

The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE)
lineages coincident with implantation of the embryo. The epiblast subsequently undergoes …

The mechanisms that control cell fate behaviour during development, and the factors
leading to their dysregulation in disease, remain the subject of interest and debate. Lately …

Epigenetic mechanisms, such as histone modifications and DNA methylation, have been
shown to play a key role in the regulation of gene transcription. Results of recent studies …

A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

Many assumptions about the way cells behave are based on analyses of populations.
However, it is now widely recognized that even apparently pure populations can display a …

Preimplantation development in mammals encompasses a period from fertilization to
implantation and results in formation of a blastocyst composed of three distinct cell lineages …

Cellular differentiation is a common underlying feature of all multicellular organisms through
which naïve cells progressively become fate restricted and develop into mature cells with …

Background During embryogenesis, the developmental potential of initially pluripotent cells
becomes progressively restricted as they transit to lineage restricted states. The pluripotent …

Precise control and maintenance of population size is fundamental for organismal
development and homeostasis. The three cell types of the mammalian blastocyst are …