The molecular processes that govern the first cell lineage decisions after fertilization also
dictate the developmental potency of stem cells derived from the early mouse embryo. Our …

Human embryonic stem cells (hESCs) have the potential to form any cell type in the body,
making them attractive cell sources in drug screening, regenerative medicine, disease and …

Single-cell profiling techniques create opportunities to delineate cell fate progression in
mammalian development. Recent studies have provided transcriptome data from human pre …

Stem cells undergo extensive self-renewal and have the capacity to differentiate along
multiple cell lineages. Progression from stem cells into differentiated progeny requires long …

During embryonic development, diffusible signaling molecules called morphogens are
thought to determine cell fates in a concentration-dependent way. Yet, in mammalian …

Cell fate decisions are fundamental for development, but we do not know how cells select
between alternate fates. Here, we asked how mouse embryonic stem (ES) cells leave the …

Embryonic stem cells (ESCs) are defined by their simultaneous capacity for limitless self-
renewal and the ability to specify cells borne of all germ layers. The regulation of ESC …

An understanding of the regulatory mechanisms responsible for pluripotency in embryonic
stem cells (ESCs) is critical for realizing their potential in medicine and science. Significant …

Background How tissue and organ sizes are specified is one of the great unsolved mysteries
in biology. Experiments and mathematical modeling implicate feedback control of cell …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …