Since the development of methods for homologous gene recombination, mouse models
have played a central role in research in renal pathophysiology. However, many published …

The increasing numbers of patients with chronic kidney disease combined with no satisfying
interventions for preventing or curing the disease emphasize the need to better understand …

The mouse is the most commonly used mammalian model to study disease, including
kidney disease. However, close attention needs to be paid to the differences and effects of …

To gain molecular insight into kidney function, we performed a high-resolution quantitative
analysis of gene expression in glomeruli and nine different nephron segments dissected …

To gain a molecular understanding of kidney functions, we established a high-resolution
map of gene expression patterns in the human kidney. The glomerulus and seven different …

Data for genes relevant to glomerular filtration barrier function or proteinuria is continually
increasing in an era of microarrays, genome‐wide association studies, and quantitative trait …

Kidney disease in the 21st century affects increasing numbers of individuals. We continue to
be challenged by our lack of understanding of the pathophysiology of acute and chronic …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …

Identifying genes underlying common forms of kidney disease in humans has proven
difficult, expensive, and time consuming. Quantitative trait loci (QTL) for several complex …

The globally increasing number of patients with end-stage renal disease urges the
identification of molecular pathways involved in renal pathophysiology, to serve as targets …