Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and
the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many …

Sphingolipids form a broad class of lipids with diverse functions ranging from membrane
constituents to intracellular second messengers and extracellular mediators. They can be …

Sphingolipids are the major constituent of the mucus secreted by the cells of epithelial
linings of lungs where they maintain the barrier functions and prevent microbial invasion …

Introduction The SARS-CoV-2 mediated COVID-19 pandemic has impacted millions
worldwide. Hyper-inflammatory processes, including cytokine storm, contribute to long …

Sphingolipids are a diverse class of signaling molecules implicated in many important
aspects of cellular biology, including growth, differentiation, apoptosis, and autophagy …

Sphingolipids are potent bioactive agents involved in the pathogenesis of various
respiratory bacterial infections. To date, several sphingolipid derivatives are known, but S1P …

Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle
them have been extensively investigated. Gas or inhaled particles or microorganisms come …

Following the discovery of ceramide as the central signaling and metabolic relay among
sphingolipids, studies of its involvement in lung health and pathophysiology have …

Sphingolipids comprise a class of bioactive lipids that are involved in a variety of
pathophysiologic processes, including cell death and survival. Ceramide and sphingosine-1 …

SARS-CoV-2 infection triggers distinct patterns of disease development characterized by
significant alterations in host regulatory responses. Severe cases exhibit profound lung …