Background Resistance to therapy remains a major cause of the failure of cancer treatment.
A major challenge in cancer therapy is to design treatment strategies that circumvent the …

The era of targeted cancer therapies has arrived. However, due to the complexity of
biological systems, the current progress is far from enough. From biological network …

Precision medicine in oncology is becoming reality thanks to the next-generation
sequencing of tumours and the development of targeted inhibitors enabling tailored …

Cancer is appreciated to be a 'Systems Disease'harboring a circuitry that is often times more
complex than that of advanced computers [1]. In most malignancies', there is a common …

The vulnerabilities of cancer at the cellular and, recently, with the introduction of
immunotherapy, at the tissue level, have been exploited with variable success. Evaluating …

Cancer is increasingly described as a systems-level, network phenomenon. Genetic
methods, such as next generation sequencing and RNA interference uncovered the …

The knowledge of cancer cell response to conventional therapies is crucial in order to
choose the correct therapy of patients affected by cancer. The major problem is generally …

Hepatocellular carcinoma (HCC) is a deadly form of liver cancer with high mortality
worldwide. Unfortunately, the large heterogeneity of this disease makes it difficult to develop …

There is a widening recognition that cancer cells are products of complex developmental
processes. Carcinogenesis and metastasis formation are increasingly described as systems …

Targeted therapies aim to prevent cancer progression by inactivating tumor-specific
signaling pathways. However, identifying a suitable drug target in the signaling network …