[HTML][HTML] NF-kappaB: two sides of the same coin

BRB Pires, RCMC Silva, GM Ferreira, E Abdelhay - Genes, 2018 - mdpi.com
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

NF-κB, an active player in human cancers

Y Xia, S Shen, IM Verma - Cancer immunology research, 2014 - AACR
NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Nuclear transcription factor-κB as a target for cancer drug development

A Garg, BB Aggarwal - Leukemia, 2002 - nature.com
Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …

NF-κB in cancer—a friend turned foe

R Ravi, A Bedi - Drug resistance updates, 2004 - Elsevier
The nuclear factor of κB (NF-κB) family of heterodimeric transcription factors plays an
instrumental role in immune, inflammatory, and stress responses. NF-κB induces the …

[HTML][HTML] Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

NF‐κB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

NF-κB in cancer: from innocent bystander to major culprit

M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

[HTML][HTML] NF-κB and cancer: a paradigm of Yin-Yang

G Xiao, J Fu - American journal of cancer research, 2011 - ncbi.nlm.nih.gov
Recent studies have clearly linked nuclear factor-kappaB (NF-κB), a transcription factor that
plays a central role in regulating immune and inflammatory responses, to tumor …

Regulation of NF-κB function

KJ Campbell, ND Perkins - Biochemical Society Symposia, 2006 - portlandpress.com
In the 20 years since its discovery, research into the NF-κB (nuclear factor-κB) family of
transcription factors has revealed an amazing diversity of functions. NF-κB proteins are …

NF-κB: tumor promoter or suppressor?

ND Perkins - Trends in cell biology, 2004 - cell.com
A role for the NF-κB family of transcription factors as tumor promoters is firmly established.
However, other data suggest that NF-κB can also inhibit tumor growth. Moreover, NF-κB …