[HTML][HTML] Morphine, a potential antagonist of cisplatin cytotoxicity, inhibits cisplatin-induced apoptosis and suppression of tumor growth in nasopharyngeal carcinoma …

LH Cao, HT Li, WQ Lin, HY Tan, L Xie, ZJ Zhong… - Scientific reports, 2016 - nature.com
Morphine is an opioid analgesic drug often used for pain relief in cancer patients. However,
there is growing evidence that morphine may modulate tumor growth, progression and …

Investigating the effects of morphine on survival and sensitivity to cisplatin in ovarian cancer cells

M Rezaeigazik, M Nabiuni, H Jalali… - Journal of Cell and …, 2019 - jcmr.um.ac.ir
Morphine as an analgesic drug is used frequently in cancer patients. Contradictory results
have been achieved from previous studies related to morphine effects in different …

Morphine stimulates cervical cancer cells and alleviates cytotoxicity of chemotherapeutic drugs via opioid receptor‐dependent and‐independent mechanisms

Z Yu, S Jin, S Tian, Z Wang - Pharmacology Research & …, 2022 - Wiley Online Library
Morphine is frequently applied in cancer patients for pain management. However, its effects
on cancer are not well understood but observed to be specific to certain cancer types. We …

Morphine can inhibit the growth of breast cancer MCF-7 cells by arresting the cell cycle and inducing apoptosis

Y Chen, Y Qin, L Li, J Chen, X Zhang… - Biological and …, 2017 - jstage.jst.go.jp
Morphine is widely used for relieving cancer pain in patients with advanced cancer.
However, whether morphine can suppress or promote the progression of cancer in breast …

Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor κB transcriptional activation in neuroblastoma SH-SY5Y cells

X Lin, Q Li, YJ Wang, YW Ju, ZQ Chi… - Biochemical …, 2007 - portlandpress.com
Morphine is recommended as a first-line opioid analgesic in the pain management of cancer
patients. Accumulating evidence shows that morphine has anti-apoptotic activity, but its …

Morphine inhibits cell viability and growth via suppression of vascular endothelial growth factor in human oral cancer HSC-3 cells

T Nishiwada, Y Kawaraguchi, K Uemura… - Journal of …, 2019 - Springer
Purpose Although many oral cancer patients require opioids, the effects of morphine and
related drugs on oral cancer progression have not been well established. Thus, we …

[HTML][HTML] Morphine Suppresses Liver Cancer Cell Tumor Properties In Vitro and In Vivo

HW Zhang, F Wang, YQ Zhou, SP Xu, SY Yu… - Frontiers in …, 2021 - frontiersin.org
Morphine is an analgesic widely adopted to relieve cancer pain. A number of discrepancies,
however, are presented by the published literature, with reports suggesting that opioids may …

Morphine: double-faced roles in the regulation of tumor development

XY Zhang, YX Liang, Y Yan, Z Dai, HC Chu - Clinical and Translational …, 2018 - Springer
Morphine, a highly potent analgesic, is one of the most effective drugs for the treatment of
severe pain associated with cancer. It directly acts on the central nervous system to relieve …

Anti-cancer effects of morphine through inhibition of tumour necrosis factor-α release and mRNA expression

N Sueoka, E Sueoka, S Okabe, H Fujiki - Carcinogenesis, 1996 - academic.oup.com
Morphine is mainly used to relieve pain in the terminal stage of cancer patients. We found
that morphine has inhibitory effects on growth of various human cancer cell lines, with IC50 …

Morphine improved the antitumor effects on MCF-7 cells in combination with 5-Fluorouracil

ZH Ge, ZX Wang, TL Yu, N Yang, Y Sun, CL Hao… - Biomedicine & …, 2014 - Elsevier
Background The most frequently used opioid in cancer pain management is morphine which
remains a cornerstone for the management of cancer pain, due to the largest experience …