Obtaining functional capillaries through the bulk has been identified as a major challenge in
tissue engineering, particularly for critical-sized defects. In the present study, a multilayered …

Our previous in vivo study showed that multilayered scaffolds made of an angiogenic layer
embedded between an osteogenic layer and an osteoconductive layer, with layer thickness …

This paper demonstrates a method to engineer, in vitro, a nascent microvasculature within a
collagen–glycosaminoglycan scaffold with a view to overcoming the major issue of graft …

Significant bone loss due to disease or traumatic injury requires surgical intervention to
modulate the natural healing process of bone. The current bone grafting options, autografts …

Survival of functional tissue constructs of clinically relevant size depends on the formation of
an organized and uniformly distributed network of blood vessels and capillaries. The lack of …

Significant bone loss due to disease or severe injury can result in the need for a bone graft,
with over 500,000 procedures occurring each year in the United States. However, the …

A key challenge in the treatment of large bone defects is the need to provide an adequate
and stable vascular supply as new tissue develops. Bone tissue engineering applies …

Editorial vascularization is the key challenge in tissue engineering (not only in bone
engineering)[10]. Vascularization can either be achieved by an extrinsic or an intrinsic …

The development of tissue engineering strategies for treatment of large bone defects has
become increasingly relevant, given the growing demand for bone substitutes. Native bone …

Adequate vascularization of scaffolds is a prerequisite for successful repair and
regeneration of lost and damaged tissues. It has been suggested that the maturity of …