Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

L Hou, SE Bergen, N Akula, J Song… - Human molecular …, 2016 - academic.oup.com
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …

Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes

EN Smith, DL Koller, C Panganiban, S Szelinger… - PLoS …, 2011 - journals.plos.org
Although a highly heritable and disabling disease, bipolar disorder's (BD) genetic variants
have been challenging to identify. We present new genotype data for 1,190 cases and 401 …

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

L Jones, K Gordon-Smith, A Perry - Nature Genetics, 2021 - eprints.worc.ac.uk
Bipolar disorder (BD) is a heritable mental illness with complex etiology. We performed a
genome-wide association study (GWAS) of 41,917 BD cases and 371,549 controls of …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

[PDF][PDF] Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q

MB McQueen, B Devlin, SV Faraone… - The American Journal of …, 2005 - cell.com
Several independent studies and meta-analyses aimed at identifying genomic regions
linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

[PDF][PDF] Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative

DM Dick, T Foroud, L Flury, ES Bowman… - The American Journal of …, 2003 - cell.com
We conducted genomewide linkage analyses on 1,152 individuals from 250 families
segregating for bipolar disorder and related affective illnesses. These pedigrees were …

Genetics of bipolar disorder: successful start to a long journey

N Craddock, P Sklar - Trends in Genetics, 2009 - cell.com
Family and twin studies attest to the importance of genetic factors influencing susceptibility to
bipolar disorder and to its genetic and phenotypic complexity. Although linkage and …

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder

DT Chen, X Jiang, N Akula, YY Shugart… - Molecular …, 2013 - nature.com
Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have
identified several genome-wide significant signals in European-ancestry samples, but so far …

Preliminary genome‐wide association study of bipolar disorder in the Japanese population

E Hattori, T Toyota, Y Ishitsuka… - American Journal of …, 2009 - Wiley Online Library
Recent progress in genotyping technology and the development of public databases has
enabled large‐scale genome‐wide association tests with diseases. We performed a two …