SARS-CoV-2 envelope protein triggers depression-like behaviors and dysosmia via TLR2-mediated neuroinflammation in mice

W Su, J Ju, M Gu, X Wang, S Liu, J Yu, D Mu - Journal of …, 2023 - Springer
Background Depression and dysosmia have been regarded as primary neurological
symptoms in COVID-19 patients, the mechanism of which remains unclear. Current studies …

Does SARS-CoV-2 affect neurodegenerative disorders? TLR2, a potential receptor for SARS-CoV-2 in the CNS

MP Szabo, M Iba, A Nath, E Masliah… - Experimental & Molecular …, 2022 - nature.com
Abstract The coronavirus (COVID-19) pandemic, caused by severe acute respiratory system
coronavirus 2 (SARS-CoV-2), has created significant challenges for scientists seeking to …

SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties

MG Frank, KH Nguyen, JB Ball, S Hopkins… - Brain, behavior, and …, 2022 - Elsevier
SARS-CoV-2 infection produces neuroinflammation as well as neurological, cognitive (ie,
brain fog), and neuropsychiatric symptoms (eg, depression, anxiety), which can persist for …

SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production

N Oka, K Shimada, A Ishii, N Kobayashi, K Kondo - Iscience, 2023 - cell.com
Neurological complications that occur in SARS-CoV-2 infection, such as olfactory
dysfunction, brain inflammation, malaise, and depressive symptoms, are thought to …

Recombinant SARS-CoV-2 Spike Protein and its Receptor Binding Domain stimulate release of different pro-inflammatory mediators via activation of distinct receptors …

I Tsilioni, TC Theoharides - Molecular Neurobiology, 2023 - Springer
SARS-CoV-2 infects cells via its spike (S) protein binding to its surface receptor angiotensin
converting enzyme 2 (ACE2) on target cells and results in acute symptoms involving …

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

J Oh, WH Cho, E Barcelon, KH Kim, J Hong, SJ Lee - Scientific reports, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accompanied
by chronic neurological sequelae such as cognitive decline and mood disorder, but the …

Encephalitis as a clinical manifestation of COVID-19

M Ye, Y Ren, T Lv - Brain, behavior, and immunity, 2020 - ncbi.nlm.nih.gov
With great interest, we read the paper “Nervous system involvement after infection with
COVID-19 and other coronaviruses”. The authors speculated that SARS-CoV-2 may cause …

Neuropathophysiology of coronavirus disease 2019: neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to …

MO Welcome, NE Mastorakis - Inflammopharmacology, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by the novel SARS-CoV-2
(severe acute respiratory syndrome coronavirus 2) first discovered in Wuhan, Hubei …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease

HO Singh, A Singh, AA Khan, V Gupta - Microbial Pathogenesis, 2021 - Elsevier
Background Long period of SARS-CoV-2 infection has been associated with psychiatric and
cognitive disorders in adolescents and children. SARS-CoV-2 remains dormant in the CNS …