Computational Modeling of Viral Infection and Immune Response in COVID-19 Patients

H Lefraich - Trends in Biomathematics: Exploring Epidemics, Eco …, 2024 - Springer
In December 2019, a novel coronavirus known as SARS-CoV-2 emerged in China and
rapidly spread worldwide, resulting in a global pandemic with a mortality rate ranging from …

[HTML][HTML] Predicting the severity of disease progression in COVID-19 at the individual and population level: A mathematical model

N Chirmule, R Khare, P Nair, B Desai… - Clinical & …, 2021 - ncbi.nlm.nih.gov
The impact of COVID-19 disease on health and economy has been global, and the
magnitude of devastation is unparalleled in modern history. Any potential course of action to …

[HTML][HTML] Within-host mathematical modeling on crucial inflammatory mediators and drug interventions in COVID-19 identifies combination therapy to be most effective …

B Chhetri, VM Bhagat, DKK Vamsi, VS Ananth… - Alexandria Engineering …, 2021 - Elsevier
The unprecedented Covid-19 pandemic has resulted in more than 14.75 million infections
and 6, 10, 839 deaths in 212 countries. Appropriate interventions can decrease the rate of …

Mathematical modeling of SARS-CoV-2 viral dynamics and treatment with monoclonal antibodies

I Kareva, A Zutshi, K Madrasi - Ifac-papersonline, 2022 - Elsevier
The novel coronavirus (SARS-CoV-2) affects primarily the respiratory tract, and if left
unchecked can cause a spectrum of pathological manifestations such as pneumonia, acute …

From Infection to Immunity: Understanding the Response to SARS-CoV2 Through In-Silico Modeling

F Castiglione, D Deb, AP Srivastava, P Liò… - Frontiers in …, 2021 - frontiersin.org
Background Immune system conditions of the patient is a key factor in COVID-19 infection
survival. A growing number of studies have focused on immunological determinants to …

Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesis

SQ Du, W Yuan - Journal of medical virology, 2020 - Wiley Online Library
We have applied mathematical modeling to investigate the infections of the ongoing
coronavirus disease‐2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 virus. We first …

Modeling Consequences of COVID-19 and Assessing Its Epidemiological Parameters: A System Dynamics Approach

AU Rehman, SH Mian, YS Usmani, MH Abidi… - Healthcare, 2023 - mdpi.com
In 2020, coronavirus (COVID-19) was declared a global pandemic and it remains prevalent
today. A necessity to model the transmission of the virus has emerged as a result of COVID …

[HTML][HTML] Burden of cytokines storm on prognosis of SARS-CoV-2 infection through immune response: dynamic analysis and optimal control with immunomodulatory …

P Rana, S Chauhan, A Mubayi - The European Physical Journal Special …, 2022 - Springer
Immune responses have a crucial role to play against SARS-CoV-2 virus as the adaptive
and innate immune systems of the human body help restoring the body to a healthy stage by …

In-host mathematical modelling of COVID-19 in humans

EA Hernandez-Vargas, JX Velasco-Hernandez - Annual reviews in control, 2020 - Elsevier
COVID-19 pandemic has underlined the impact of emergent pathogens as a major threat to
human health. The development of quantitative approaches to advance comprehension of …

Model-based cellular kinetic analysis of SARS-CoV-2 infection: different immune response modes and treatment strategies

Z Zhou, Z Zhao, S Shi, J Wu, D Li, J Li, J Zhang… - arXiv preprint arXiv …, 2021 - arxiv.org
Increasing number in global COVID-19 cases demands for mathematical model to analyze
the interaction between the virus dynamics and the response of innate and adaptive …