Control intervention strategies for within-host, between-host and their efficacy in the treatment, spread of COVID-19: A multi scale modeling approach

DB Prakash, DKK Vamsi, DB Rajesh… - Computational and …, 2020 - degruyter.com
The COVID-19 pandemic has resulted in more than 65.5 million infections and 15, 14,695
deaths in 212 countries over the last few months. Different drug intervention acting at …

Mechanistic modeling of the SARS-CoV-2 and immune system interplay unravels design principles for diverse clinicopathological outcomes

S Sahoo, K Hari, S Jhunjhunwala, MK Jolly - BioRxiv, 2020 - biorxiv.org
The disease caused by SARS-CoV-2 is a global pandemic that threatens to bring long-term
changes worldwide. Approximately 80% of infected patients are asymptomatic or have mild …

Modeling and simulations of CoViD-19 molecular mechanism induced by cytokines storm during SARS-CoV2 infection

Z Yu, R Ellahi, A Nutini, A Sohail, SM Sait - Journal of molecular liquids, 2021 - Elsevier
It is highly desired to explore the interventions of COVID-19 for early treatment strategies.
Such interventions are still under consideration. A model is benchmarked research and …

[HTML][HTML] A multi-method approach to modeling COVID-19 disease dynamics in the United States

A Mokhtari, C Mineo, J Kriseman, P Kremer, L Neal… - Scientific reports, 2021 - nature.com
In this paper, we proposed a multi-method modeling approach to community-level spreading
of COVID-19 disease. Our methodology was composed of interconnected age-stratified …

[HTML][HTML] Intracellular life cycle kinetics of SARS-CoV-2 predicted using mathematical modelling

D Grebennikov, E Kholodareva, I Sazonov… - Viruses, 2021 - mdpi.com
SARS-CoV-2 infection represents a global threat to human health. Various approaches were
employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and …

Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response

VI Zarnitsyna, JF Gianlupi, A Hagar, TJ Sego… - Current opinion in …, 2021 - Elsevier
The COVID-19 pandemic has highlighted a need for improved frameworks for drug
discovery, repurposing, clinical trial design and therapy optimization and personalization …

Dynamical characterization of antiviral effects in COVID-19

P Abuin, A Anderson, A Ferramosca… - Annual reviews in …, 2021 - Elsevier
Mathematical models describing SARS-CoV-2 dynamics and the corresponding immune
responses in patients with COVID-19 can be critical to evaluate possible clinical outcomes of …

[HTML][HTML] Simulation and forecasting models of COVID-19 taking into account spatio-temporal dynamic characteristics: A review

P Wang, X Zheng, H Liu - Frontiers in public health, 2022 - frontiersin.org
The COVID-19 epidemic has caused more than 6.4 million deaths to date and has become a
hot topic of interest in different disciplines. According to bibliometric analysis, more than …

Comparing antiviral strategies against COVID-19 via multiscale within-host modelling

F Fatehi, RJ Bingham, EC Dykeman… - Royal Society …, 2021 - royalsocietypublishing.org
Within-host models of COVID-19 infection dynamics enable the merits of different forms of
antiviral therapy to be assessed in individual patients. A stochastic agent-based model of …

[HTML][HTML] Dynamics models for identifying the key transmission parameters of the COVID-19 disease

M Shahzad, AH Abdel-Aty, RAM Attia… - Alexandria Engineering …, 2021 - Elsevier
After the analysis and forecast of COVID-19 spreading in China, Italy, and France the WHO
has declared the COVID-19 a pandemic. There are around 100 research groups across the …