Objective To systematically review the literature relating to the impact of multiple co-
occurring modifiable risk factors for cognitive decline and dementia. Design A systematic …

Background Dementia and cognitive impairment can be attributed to genetic and modifiable
factors. Considerable evidence emerged in modifiable factors and urgently requires …

Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

Multimorbidity (the presence of two or more long-term conditions [LTCs]) was suggested to
exacerbate the neuronal injuries. The impact of multimorbidity on dementia has not been …

An estimated 47 million people worldwide are living with dementia in 2015, and this number
is projected to triple by 2050. In the absence of a disease-modifying treatment or cure …

Introduction Cognitive impairment and frailty are important health determinants,
independently associated with increased dementia risk. In this meta-analysis we aimed to …

Previous hypothesis-driven research has identified many risk factors linked to dementia.
However, the multiplicity and co-occurrence of risk factors have been underestimated. Here …

Introduction Stroke is an established risk factor for all-cause dementia, though meta-
analyses are needed to quantify this risk. Methods We searched Medline, PsycINFO, and …

Objective The challenges posed by people living with multiple chronic conditions are unique
for people with dementia and other significant cognitive impairment. There have been recent …

Background Information from well-established dementia risk models can guide targeted
intervention to prevent dementia, in addition to the main purpose of quantifying the …