Rationale. A deregulation in concentrations of the neurosteroids (allo) pregnanolone and
3α, 5α-tetrahydrodeoxycorticosterone (3α, 5α-TH DOC) has been found in depressed …

In addition to the well-known genomic effects of steroid molecules, certain neuroactive
steroids control neurotransmission through the modulation of specific neurotransmitter …

Neuroactive steroids modulate neurotransmission through modulation of specific
neurotransmitter receptors such as γ-aminobutyric acid type A (GABAA) receptors …

Besides their binding to cognate intracellular receptors gonadal steroids may also act as
functional antagonists at the 5-HT3 receptor. A structure–activity relationship for the actions …

The naturally occurring 3α-reduced neurosteroids allopregnanolone and its isomer
pregnanolone are among the most potent positive allosteric modulators of γ-aminobutyric …

Anxiety disorders are the most common psychiatric disorders. They are frequently treated
with benzodiazepines, which are fast acting highly effective anxiolytic agents. However, their …

In the past decades considerable evidence has emerged that so-called neuroactive steroids
do not only act as transcriptional factors in the regulation of gene expression but may also …

OBJECTIVE: There is evidence from animal studies that fluoxetine may enhance the
concentrations of neuroactive steroids. Therefore, the authors investigated whether clinically …

Benzodiazepines remain the most frequently used psychotropic drugs for the treatment of
anxiety spectrum disorders; however, their use is associated with the development of …

Neurosteroids are important neuroactive substrates with demonstrated involvement in
several neurophysiological and disease processes. Attention deficit hyperactivity disorder …