The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

Introduction: SOX2 is a transcription factor that is important in the development and
maintenance of the stem cell state. Furthermore, SOX2 is associated with cancer …

SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

The transcription factor Sox2 plays an important role in various phases of embryonic
development, including cell fate and differentiation. These key regulatory functions are …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

The Sry-containing protein Sox2 initially was known to regulate the self-renewal of the
mouse and human embryonic stem cells (ESCs). It is also important for the maintenance of …

SOX2 is a master pluripotency controller that was recently identified as a novel major
oncogene, recurrently amplified and activated in Squamous Cell Carcinoma (SCC). These …