Insights into a class of natural eugenol and its optimized derivatives as potential tobacco mosaic virus helicase inhibitors by structure-based virtual screening
Z Li, B Yang, Y Ding, J Meng, J Hu, X Zhou, L Liu… - International Journal of …, 2023 - Elsevier
Plant diseases caused by malignant and refractory phytopathogenic viruses have
considerably restricted crop yields and quality. To date, drug design targeting functional …
considerably restricted crop yields and quality. To date, drug design targeting functional …
Screening anti-TMV agents targeting tobacco mosaic virus helicase protein
D Wang, M Huang, D Gao, K Chen, W Xu, X Li - Pesticide biochemistry …, 2020 - Elsevier
Tobacco mosaic virus helicase (TMV-Hel) plays important roles in viral multiplication. TMV-
Hel is a potential target of anti-TMV agents. Our previous studies expressed and purified …
Hel is a potential target of anti-TMV agents. Our previous studies expressed and purified …
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target
D Vlachakis, S Kossida - PeerJ, 2013 - peerj.com
Abstract The Classical Swine Fever virus (CSFV) is a major pathogen of livestock and
belongs to the flaviviridae viral family. Even though there aren't any verified zoonosis cases …
belongs to the flaviviridae viral family. Even though there aren't any verified zoonosis cases …
Plant-based analogues identified as potential inhibitor against tobacco mosaic virus: A biosimulation approach
J Sharma, VK Bhardwaj, P Das, R Purohit - Pesticide Biochemistry and …, 2021 - Elsevier
Benzosuberene compounds with a pyrrolone group adhered to it are compounds extracted
from the oils of Cedrus deodara plant, that bear inhibitory capabilities. Tobacco mosaic virus …
from the oils of Cedrus deodara plant, that bear inhibitory capabilities. Tobacco mosaic virus …
Design, synthesis, anti-tobacco mosaic viral and molecule docking simulations of urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro …
V Nagalakshmamma, M Venkataswamy, C Pasala… - Bioorganic …, 2020 - Elsevier
The objectives of the present work are to design, syhthesize and introduce novel
urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl) …
urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl) …
Targeting dengue virus NS-3 helicase by ligand based pharmacophore modeling and structure based virtual screening
Dengue fever is an emerging public health concern, with several million viral infections
occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) …
occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) …
In vivo antiviral activity and disassembly mechanism of novel 1-phenyl-5-amine-4-pyrazole thioether derivatives against Tobacco mosaic virus
Z Wu, W Yang, S Hou, D Xie, J Yang, L Liu… - Pesticide Biochemistry …, 2021 - Elsevier
A series of novel 1-phenyl-5-amine-4-pyrazole thioether derivatives containing a 1, 3, 4-
oxadiazole moiety was designed and synthesised. In vivo antiviral bioassay results showed …
oxadiazole moiety was designed and synthesised. In vivo antiviral bioassay results showed …
Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation
KG Byler, JT Collins, IV Ogungbe, WN Setzer - Computational Biology and …, 2016 - Elsevier
Alphaviruses such as Chikungunya virus (CHIKV), O'Nyong–Nyong virus (ONNV), Ross
River virus (RRV), Eastern equine encephalitis virus (EEEV), Venezuelan equine …
River virus (RRV), Eastern equine encephalitis virus (EEEV), Venezuelan equine …
Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus
The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes viral
encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA …
encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA …
Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target
The nonstructural protein 3 (NS3) of hepatitis C virus (HCV) helicase is believed to be
essential for viral replication and has become an attractive target for the development of …
essential for viral replication and has become an attractive target for the development of …