H2O2 and other reactive oxygen species are key regulators of many intracellular pathways.
Within mammalian skin, H2O2 is formed as a byproduct of melanin synthesis, and following …

UV‐induced DNA damage can lead to melanoma, the most dangerous form of skin cancer.
Understanding the mechanisms employed by melanocytes to protect against UV is therefore …

Treatment of human melanoma cells with the differentiation‐inducing agent hexamethylene
bisacetamide (HMBA) results in reciprocal changes in expression of melanocyte‐specific …

Constitutive pigmentation determines the response to sun exposure and the risk for
melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes …

Melanocytes are producing melanin after UV irradiation as a defense mechanism. However,
UV-induced damage is involved in melanoma initiation, depending on skin phototype …

Exposure of cultured human melanocytes to ultraviolet radiation (UV) results in DNA
damage. In melanoma, UV‐signature mutations resulting from unrepaired photoproducts are …

Melanocytes play a central role in the response of skin to sunlight exposure. They are
directly involved in UV‐induced pigmentation as a defense mechanism. However, their …

The microphthalmia-associated transcription factor is implicated in melanocyte development
and in the regulation of melanogenesis. Microphthalmia-associated transcription factor is …

Upregulation of microphthalmia-associated transcription factor (MITF) expression has been
proposed to mediate melanogenesis stimulated by cAMP, whereas downregulation of MITF …

Ultraviolet light (UV) radiation causes skin‐tanning, which is thought to be mediated by
stimulating the release of melanogenic factors from keratinocytes as well as other cells …