Empagliflozin attenuates doxorubicin-induced cardiotoxicity

VÖ Barış, AB Dinçsoy, E Gedikli, S Zırh… - Toxicology …, 2023 - academic.oup.com
In previous issues of the journal, we have just read with great interest the paper by chen
entitled “Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating …

[PDF][PDF] Potential Role of Empagliflozin to Ameliorate Doxorubicin Induced Cardiotoxicity in Male Rats

RN Albakaa, FA Rizij, RMA Hassan - J. Med. Chem. Sci, 2023 - researchgate.net
Empagliflozin (EMPA), a selective inhibitor of the sodium-glucose co-transporter 2, is
especially effective at regulating blood-sugar levels [1]. Compared to conventional optimum …

Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis

M Chen - Toxicology Research, 2023 - academic.oup.com
We aimed to probe the functions and possible mechanisms of empagliflozin in doxorubicin
(Dox)-caused cardiotoxicity. First, a cardiotoxicity rat model was built by continuously …

Empagliflozin significantly prevents the doxorubicin-induced acute cardiotoxicity via non-antioxidant pathways

VÖ Barış, AB Dinçsoy, E Gedikli, S Zırh… - Cardiovascular …, 2021 - Springer
Empagliflozin (EMPA) is a SGLT-2 inhibitor that has positive effects on cardiovascular
outcomes. In this study, we aim to evaluate the possible protective effects of EMPA against …

Empagliflozin prevents doxorubicin-induced myocardial dysfunction

J Sabatino, S De Rosa, L Tammè, C Iaconetti… - Cardiovascular …, 2020 - Springer
Background Empagliflozin showed efficacy in controlling glycaemia, leading to reductions in
HbA1c levels, weight loss and blood pressure, compared to standard treatment. Moreover …

[HTML][HTML] Empagliflozin attenuates doxorubicin-induced cardiotoxicity by inhibiting the JNK signaling pathway

HY Chang, HC Hsu, YH Fang, PY Liu, YW Liu - Biomedicine & …, 2024 - Elsevier
Background Sodium-glucose cotransporter-2 inhibitors, such as empagliflozin, are pivotal
therapies for heart failure. However, the effect of empagliflozin on doxorubicin-related …

Empaglifozin has cardioprotective and anti-inflammatory effects during doxorubicin treatment: A preclinical study.

N Maurea, V Quagliariello, C Coppola, D Rea… - 2019 - ascopubs.org
e23057 Background: Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-
transporter 2 (SGLT2), reduces the risk of hospitalization for heart failure or cardiovascular …

[HTML][HTML] Cardioprotective and anti-inflammatory effects of empagliflozin during treatment with doxorubicin: A cellular and preclinical study

V Quagliariello, C Coppola, D Rea, C Maurea… - Annals of …, 2019 - Elsevier
Background Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter
2, reduces the risk of hospitalization for heart failure or cardiovascular death, as seen in the …

P5716 Cardioprotective anti inflammatory effects of empaglifozin in doxorubicin induced cardiotoxicity: the role of leukotriene B4 and interleukin 1

N Maurea, V Quagliariello, C Coppola… - European Heart …, 2019 - academic.oup.com
Background Empagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter
2 (SGLT2), reduces the risk of hospitalization for heart failure or cardiovascular death in type …

Role of hypoxia inducible factor/vascular endothelial growth factor/endothelial nitric oxide synthase signaling pathway in mediating the cardioprotective effect of …

MM Mahmoud Refaie, AMA Bayoumi… - Human & …, 2023 - journals.sagepub.com
Background Cyclophosphamide (CP) is a commonly used chemotherapeutic and
immunosuppressive alkylating agent. However, cardiac adverse effects of CP interfere with …