In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …

Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

Metallodrugs offer potential for unique mechanism of drug action based on the choice of the
metal, its oxidation state, the types and number of coordinated ligands and the coordination …

Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

More than 99% of currently approved clinical drugs are organic compounds. In contrast, the
percentage of metal-containing drugs (metallodrugs) is very low. In cancer chemotherapy …

The development of metal complexes with platinum central atoms such as cisplatin or
carboplatin had an enormous impact on current cancer chemotherapy. However, the …

Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …

This review illustrates notable recent progress in the field of medicinal bioinorganic
chemistry as many new approaches to the design of innovative metal-based anticancer …

Metal-based anticancer drugs are among the most successful therapeutic agents, as
evidenced by the frequent prescription of selected platinum and arsenic compounds to …