Pharmacology and Therapeutics (Figure 1) provides a tour of selected innovations in
precision medicine, model-informed drug discovery and development frameworks, and the …

Highlights•Select the trial for the patient, not the patient for the trial.•A new paradigm of
patient-centric drug development, as precision medicine continues to shape the oncology …

Toward Patient-Centered Drug Development in Oncology | New England Journal of
Medicine Skip to main content Access provided byTE WHATU ORA HEALTH NEW …

Cancer treatment is gradually evolving from the classical use of nonspecific cytotoxic drugs
targeting generic mechanisms of cell growth and proliferation. Instead, new “patient‐specific …

For almost 15 years I have been working, as an associate editor, with the editorial
leadership of Pharmacological Reviews. Not only has it been an honor and privilege to work …

Precision or personalized medicine is a strategy that allows the selection of specific
treatments based on the patient's genetic or genomic changes that may occur in an …

Despite advances in biomedical research that have deepened our understanding of cancer
hallmarks, resulting in the discovery and development of targeted therapies, the success …

Precision medicine refers to the “tailoring of medical treatment to the individual
characteristics of each patient.” 1 Because cancer is a disease of the genome, 2 molecular …

Fueled by the pan-cancer genomics landscape, druggable targets discovered in The Cancer
Genome Atlas (TCGA), and great successes of clinically actionable pharmacokinetic …

The primary objective of any treatment in oncology is the improve patients' overall survival
(OS) and/or quality of life (QoL). Patients with solid tumors may often be cured thanks to local …