G protein-coupled receptor 35 (GPR35), a receptor for lysophosphatidic acid, is highly
expressed in the gastrointestinal tract. Recently, GPR35 has been implicated in the onset of …

Background G protein-coupled receptor 35 (GPR35) is an orphan receptor and is vastly
expressed in immune cells and gastrointestinal cells, suggesting the potential physiological …

At mucosal sites such as the intestine, the immune system launches robust immunity against
invading pathogens while maintaining a state of tolerance to commensal flora and ingested …

G protein-coupled receptor (GPR) 40 is a receptor for long-chain free fatty acids that
enhances glucagon-like peptide (GLP)-2 production in intestinal L-cells. GLP-2 and its …

Abstract Background and Aims During active inflammation, intraluminal intestinal pH is
decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …

Inflammatory bowel disease (IBD) is characterized by chronic, recurring inflammation of the
digestive tract. Current therapeutic approaches are limited and include biologics and …

BACKGROUND: G protein-coupled receptor 55 (GPR55) is a lysophospholipid receptor
responsive to certain cannabinoids. The role of GPR55 in inflammatory processes of the gut …

GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated
by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism …

Background & Aims: G protein-coupled receptor 30 (GPR30) is a recently de-orphanized
estrogen receptor that mediates the effects of estrogens on different cells. It has been …